• Matamales bioRxiv 2019
    MEMORY UPDATING | EXTINCTION 

    A binary mosaic in the striatum to reshape goal-directed learning

    Matamales M, McGovern AE, Mi JD, Mazzone SB, Balleine BW & Bertran-Gonzalez J (2020) Science

    In this study we uncover previously unrecognised large-scale interactions between D1- and D2- neurons within functionally relevant striatal territories, that are critical to reshape volitional action.

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  • Matamales eLife 2017
    SEQUENCE LEARNING | AGEING

    Strategies of the aged brain to produce action sequences

    Matamales M, Skrbis Z, Bailey MR, Balsam PD, Balleine BW, Götz J & Bertran-Gonzalez J (2017) eLife

    Detailed analysis of the acquisition of a skilled behaviour revealed that age introduces temporal limits to action automaticity. An action-related feedback cue temporarily restored normal sequence structure.

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  • Matamales PlosOne 2016
    INTERNEURONS | QUANTITIVE IMAGING

    Whole map reconstruction of the striatal cholinergic population

    Matamales M, Götz J & Bertran-Gonzalez J (2016) PLoS ONE

    We mapped and digitally reconstructed the entire population of cholinergic interneurons in the mouse striatum and discovered functional territory-dependent differences in distribution and neuronal activity.

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  • Matamales Neuron 2016
    REVERSAL LEARNING | AGEING

    Why older individuals struggle to adapt to change?

    Matamales M*, Skrbis Z*, Hatch RJ, Balleine BW, Götz J & Bertran-Gonzalez J (2016) Neuron

    We found that age-related decline in the thalamic-to-striatal pathway impairs the ability of mice to adjust to environmental changes in goal-directed learning tasks. Cholinergic interneurons play a critical role in this process. 

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  • Bertran-Gonzalez JNeurosci 2008
    NEURONAL SUBPOPULATIONS | DRUGS

    Patterns of activation in striatal neurons by cocaine and haloperidol

    Bertran-Gonzalez J, Bosch C,  Maroteaux M, Matamales M, Hervé D, Valjent E & Girault JA (2008) JNeurosci

    We demonstrated the existence of a complete segregation between the striatonigral and striatopallidal circuits within the striatum in response to pharmacological stimuli using BAC-EGFP transgenic mice.

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  • Nature 2008
    CELL SIGNALLING | DOPAMINE

    A novel mechanism by which dopamine alters chromatin in neurons

    Stipanovich A*, Valjent E*, Matamales M* […] Greengard P, Hervé D & Giratul JA (2008) Nature

    We discovered that the dopamine-dependent regulated accumulation in the nucleus of a protein phosphatase inhibitor is key to encode drug and natural rewarding stimuli in striatal neurons.

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  • Matamales Plos 2009
    STRIATAL NEURONS | NEUROANATOMY

    Nuclear architecture diversity in the mouse striatum

    Matamales M*, Bertran-Gonzalez J* […] Valjent E, Hervé D & Girault JA (2009) PLoS ONE

    We showed that nuclear stain could distinguish the different neuronal populations of the striatum. We used this technique to precisely analyse BAC-transgenic lines for their application in neuroscience research.

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GRANT FUNDING
Our work is supported by the Australian Research Council and the National Health and Medical Research Council. Click for details

RESEARCH ETHICS & SAFETY
All experimental procedures are approved by the Animal Care and Ethics Commitee and the Gene Technology Research Commitee at UNSW.

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