Restoring goal-direction encoding in aged striatal circuits.
Bertran-Gonzalez J, Dinale C & Matamales M (2022) bioRxiv
We found that D1- and D2-neurons of the aged striatum present a counterbalanced plasticity that promotes autonomous —habit-like—behaviours. Targeting the cellular state of D2-neurons invigorates goal-directed action.
Detailed analysis of the acquisition of a skilled behaviour revealed that age introduces temporal limits to action automaticity. An action-related feedback cue temporarily restored normal sequence structure.
Whole map reconstruction of the striatal cholinergic population
Matamales M, Götz J & Bertran-Gonzalez J (2016) PLoS ONE
We mapped and digitally reconstructed the entire population of cholinergic interneurons in the mouse striatum and discovered functional territory-dependent differences in distribution and neuronal activity.
We found that age-related decline in the thalamic-to-striatal pathway impairs the ability of mice to adjust to environmental changes in goal-directed learning tasks. Cholinergic interneurons play a critical role in this process.
Patterns of activation in striatal neurons by cocaine and haloperidol
Bertran-Gonzalez J, Bosch C, Maroteaux M, Matamales M, Hervé D, Valjent E & Girault JA (2008) JNeurosci
We demonstrated the existence of a complete segregation between the striatonigral and striatopallidal circuits within the striatum in response to pharmacological stimuli using BAC-EGFP transgenic mice.
Nuclear architecture diversity in the mouse striatum
Matamales M*, Bertran-Gonzalez J* […] Valjent E, Hervé D & Girault JA (2009) PLoS ONE
We showed that nuclear stain could distinguish the different neuronal populations of the striatum. We used this technique to precisely analyse BAC-transgenic lines for their application in neuroscience research.